Genetic Risk analysis for Breast, Bowel and Melanoma Cancers

The Better2Know Genetic Cancer Risk analysis for women will reveal your unique genetic risk for three types of common cancer that affect women. You will receive tailored medical recommendations designed to empower you with effective strategies for prevention and early detection. This analysis uses polygenic risk scoring (PRS) based on hundreds of common genetic variants, giving you the most reliable indicators of cancer risk available.

The Better2Know personalised Genetic Cancer Risk analysis for women will assess your risk for:

• Breast cancer
• Bowel cancer
• Melanoma cancer

What are the cancers that this test will assess?

Breast cancer is a disease affecting the breasts of women and rarely of men. This disease generally starts in the cells that line the milk producing ducts inside the breast. When these cells start to grow and multiply out of control, they can form masses of tissue referred to as tumors. These cancerous cells can spread to other parts of the body leading to the formation of tumors in other organs.

Breast cancer is the most common cancer in women but only half of all cases are detected early. Currently around 20% of all breast cancer cases in the United Kingdom are diagnosed in women under the age of 50, indicating the importance of early risk identification.

Bowel or colon cancer is cancer found anywhere in the large bowel, the lower part of your intestine which includes the colon and rectum. It's one of the most common types of cancer in the UK affecting 4% of all women and men. Bowel cancer is one of the leading causes of cancer relate death with over 50% of cases considered to be preventable.

Melanoma cancer is a type of skin cancer. Melanoma cancer is primarily caused by excess exposure to ultraviolet light from the sun or tanning beds. Melanoma cancer is the most dangerous kind of skin cancer as it can quickly spread, if not detected early, to other parts of your body. Melanoma accounts for 5% of all cancers detected in the United Kingdom and Ireland. Melanoma rates have risen sharply in recent years, but nearly 90% of all cases are deemed to be preventable with early risk assessment.

Why should I choose personalised prevention?

Every woman is different and each of us has our own unique risk profile for developing certain diseases and cancers. This polygenic risk test will determine your personal genetic risk of developing certain cancers. Inherited genetic mutations are the cause of 10–15% of most cancers. Finding out that you have a mutation that increases your risk, enables you and your healthcare provider to develop a personalised plan designed to prevent or detect cancer at an earlier stage.

• Discover your genetic risk level for breast cancer, bowel cancer, and melanoma
• Powered by clinical-grade, MHRA registered, CE-marked genetic testing from a saliva sample collected at home
• Get personalised guidance on when to start screening and how often
• Learn actionable steps to reduce your risk
• Recommended for women aged 35 and above regardless of family history

Take the first step – order your personalised prevention plan today!

The Reality of Cancer for women

• Breast cancer is the most common cancer in women.
• Bowel cancer is the third most common cancer in women.
• Melanoma skin cancer is the 5th most common cancer in women, with 1 in every 47 women developing melanoma in her lifetime
• Up to 50% of cancers are preventable with early measures.

We Can Change This – With Personalised Prevention!

Next-Generation Prevention: Tailored to Your Unique Genetic Profile

Personalised cancer prevention with genetic risk assessment provides early warnings, even in individuals with no family history of cancer. Our tests guide you toward tailored screening and prevention strategies based on your unique risk level.

What is a Polygenic Risk Score?

The Polygenic Risk Score (PRS) measures disease risk based on the analysis of hundreds of genetic variants. Our PRS technology calculates the combined effect of these variants to determine your personalised risk score for developing certain cancers.

• Many cancers result from a combination of multiple genetic factors, making them polygenic.
• Even without a family history of cancer, your polygenic risk may still be significant.
• Incorporating PRS with your background (age, sex, ethnicity), we provide accurate risk assessments and tailored medical advice.

Who should take this test?

• Women aged 35 and above, regardless of family history
• Those who want to be proactive about their health
• Anyone seeking personalised medical prevention strategies

What is the Better2Know Personalised Cancer Prevention Plan for Women testing process?

Follow these three simple steps to your personalised cancer prevention plan

• Order your test kit today and have it delivered directly to your home.
• Provide a saliva sample using the simple saliva collection kit and return it using the enclosed prepaid envelope.
• Receive your personalised report online within six weeks, complete with clear guidance on your next steps. Each report includes your polygenic risk level, screening recommendations, and lifestyle guidance.

Certified and Trusted Testing with Better2Know

Our tests are fully compliant with all regulatory bodies and are government-approved

• CE-marked medical devices (in vitro diagnostics, IVD)
• Registered in the UK MHRA Registry and EUDAMED database
• Developed using anonymised data from the UK Biobank ensuring high accuracy and applicability

Comprehensive Insights on your genetic risks await you:

• What is your genetic risk level for breast cancer, bowel cancer, and melanoma?
• When should you start screening, and how often?
• Are there additional measures you can take to lower your risk?
• What steps can you take to reduce your likelihood of developing these cancers?
• What changes or symptoms should you monitor?
• What should your doctor know?

When will my home testing kit arrive?

If you order before 4pm, Monday to Friday, we can send your cancer panel test on the very same day, by sending your test by First Class Royal Mail.

How will I receive my test results?

You will receive your test results around 6–8 weeks once our lab has received your sample. You will be notified via email once your results are available.

What should I do with my results?

If your test shows that you are at increased risk of developing breast, bowel or melanoma cancer, optional genetic counselling is provided for those identified as being at elevated risk.

How can I order my home test?

You can order your personalised cancer prevention plan for women by adding the test to your basket and proceeding to payment. You can also call Better2Know on the number displayed at the top of the page. Our team of expert advisors will be able to help you process your order and answer any additional questions. For your convenience, our lines are open 24/7.

Frequently Asked Questions

• How long is my saliva sample stable for during transit? Saliva samples remain stable for up to 6 months under suitable conditions.
• When will I receive my test results? Once your sample is received at the laboratory, results are typically reported within 6 – 8 weeks. If you haven’t received your results after this time, please contact us.
• How will I get my results? Your comprehensive tet report will be sent to you within 6 weeks of you submitting your sample. If needed, our medical team will contact you to arrange a convenient time to discuss your results.
• Does this test analyse rare mutations in genes that increase cancer risk? No, the test evaluates your polygenic risk score but does not assess rare pathogenic mutations in genes that significantly increase cancer risk.
• Is this test used to diagnose cancer? No, this test does not assess rare, high-impact mutations (e.g., BRCA, Lynch). For those, monogenic testing may be appropriate. This test is designed to assess your genetic predisposition and provide personalised prevention strategies, not diagnose cancer.
• Does an elevated risk mean I will develop cancer? No, an elevated risk does not guarantee you will develop cancer. Similarly, a moderate or lower risk does not mean your risk is zero.
• Does this test assess the risk for my family members? No, the test evaluates your personal risk. Polygenic risk scores are not directly inherited in a way that can predict risks for relatives.
• What else should I consider alongside my test results? Your test results should be interpreted alongside other clinical data. Lifestyle, diet, and other health factors also play a role in cancer risk.