Genetic Risk analysis for Prostate Cancer.

The Better2Know Personalised Prostate Genetic Cancer Risk analysis for men will reveal your unique genetic risk for Prostate Cancer, the most common cancer in men. You will receive tailored medical recommendations designed to empower you with effective strategies for prevention and early detection. This analysis uses polygenic risk scoring (PRS) based on hundreds of common genetic variants, giving you the most reliable indicators of prostate cancer risk available.

The Better2Know personalised Genetic Cancer Risk analysis for men will assess your risk for:

• Prostate Cancer

What is the cancer that this test will assess?

Prostate cancer is a cancer of the prostate gland, part of the male reproductive system. Cancer is when abnormal cells divide and grow into surrounding tissues or organs and may also spread to other parts of the body. Prostate cancer is the most common cancer in men in the United Kingdom with more than 20% of men developing this disease in their lifetime.

Prostate Cancer is the second leading cause of cancer related deaths amongst men. Men with a high genetic risk of developing Prostate Cancer are up to three times more likely to die from Prostate Cancer than they are if they received an early risk assessment and intervention.

Prostate Cancer is treatable and often curable. This means that with early detection, your risk of dying from Prostate Cancer can be significantly reduced. The important thing you need to do is to first understand if you are predisposed to Prostate Cancer by taking this genetic test. You will learn if you carry common genetic variants that, together, increase your risk of developing prostate cancer. This early warning of prostate cancer risk can save your life. If you are at risk, then you should undertake periodic testing to ensure your prostate is not starting to develop cancer.

Why should I choose personalised prevention?

Every person is different and each of us has our own unique risk profile for developing certain diseases and cancers. This polygenic risk test will determine your personal genetic risk of developing prostate cancer. Inherited genetic variations are the cause of 10–15% of most cancers. Finding out that you have a variation that increases your risk, enables you and your healthcare provider to develop a personalised plan designed to prevent or detect prostate cancer at an earlier stage.

• Discover your genetic risk level for prostate cancer.
• Powered by clinical-grade, MHRA registered, CE-marked genetic testing from a saliva sample collected at home
• Get personalised guidance on when to start screening and how often
• Learn actionable steps to reduce your risk under the guidance of licensed doctors
• Recommended for men aged 40 and above

Take the first step – order your personalised prevention plan today!

The Reality of Cancer for Men

• Prostate cancer is the most common cancer in men.
• Prostate cancer is the second leading cause of cancer related deaths in men .
• Men with an elevated genetic risk of prostate cancer are three times more likely to die from prostate cancer.
• Up to 50% of cancers are preventable with early measures.

We Can Change This – With Personalised Prevention!

Next-Generation Prevention: Tailored to Your Unique Genetic Profile

Personalised cancer prevention with genetic risk assessment provides early warnings, even in individuals with no family history of cancer. Our tests guide you toward tailored screening and prevention strategies based on your unique risk level.

What is a Polygenic Risk Score?

The Polygenic Risk Score (PRS) measures disease risk based on the analysis of hundreds of genetic variants. Our PRS technology calculates the combined effect of these variants to determine your personalised risk score for developing prostate cancer.

• Many cancers result from a combination of multiple genetic factors, making them polygenic.
• Even without a family history of cancer, your polygenic risk may still be significant.
• Incorporating PRS with your background (age, sex, ethnicity), we provide accurate risk assessments and tailored medical advice.

Who should take this test?

• Men aged 40 and above, regardless of family history
• Those who want to be proactive about their health
• Anyone concerned about their prostate health
• Anyone seeking personalised medical prevention strategies

What is the Better2Know Personalised Prostate Cancer Prevention Plan for Men testing process?

Follow these three simple steps to your personalised cancer prevention plan

• Order your test kit today and have it delivered directly to your home.
• Provide a saliva sample using the simple saliva collection kit and return it using the enclosed prepaid envelope.
• Receive your personalised report online within six to eight weeks, complete with clear guidance on your next steps. Each report includes your polygenic risk level, screening recommendations, and lifestyle guidance.

Certified and Trusted Testing with Better2Know

Our tests are fully compliant with all regulatory bodies and are government-approved

• CE-marked medical devices (in vitro diagnostics, IVD)
• Registered in the UK MHRA Registry and EUDAMED database
• Developed using anonymised data from the UK Biobank ensuring high accuracy and applicability

Comprehensive Insights on your genetic risks of developing prostate cancer await you:

• What is your genetic risk level for prostate cancer?
• When should you start screening, and how often?
• Are there additional measures you can take to lower your risk?
• What steps can you take to reduce your likelihood of developing prostate cancer?
• What changes or symptoms should you monitor?
• What should your doctor know?

When will my home testing kit arrive?

When you order your test, Monday to Friday, we will send your cancer panel test the very next day, sending your test by First Class Royal Mail.

How will I receive my test results?

You will receive your comprehensive results report around 6–8 weeks once our lab has received your sample.

What should I do with my results?

If your test shows that you are at increased risk of developing prostate cancer, optional genetic counselling can be provided for those identified as being at elevated risk.

How can I order my home test?

You can order your personalised prostate cancer prevention plan for men by adding the test to your basket and proceeding to payment. You can also call Better2Know on the number displayed at the top of the page. Our team of expert advisors will be able to help you process your order and answer any additional questions. For your convenience, our lines are open 24/7.

Frequently Asked Questions

• How long is my saliva sample stable for during transit? Saliva samples remain stable for up to 6 months under suitable conditions.
• When will I receive my test results? Once your sample is received at the laboratory, results are typically reported within 6 – 8 weeks. If you haven’t received your results after this time, please contact us.
• How will I get my results? You can access your results online within 6 - 8 weeks. The notification about your results will be sent to the email address you provided. If needed, our medical team will contact you to arrange a convenient time to discuss your results.
• Does this test analyse rare mutations in genes that increase cancer risk? No, the test evaluates your polygenic risk score but does not assess rare pathogenic mutations in genes such as BRCA1, BRCA2, ATM, and others which may be assessed separately via referral to a genetic counsellor if indicated by family history.
• Is this test used to diagnose cancer? No, this test does not assess rare, high-impact mutations. For those, monogenic testing may be appropriate. This test is designed to assess your genetic predisposition and provide personalised prevention strategies, not diagnose prostate cancer.
• Does an elevated risk mean I will develop cancer? No, an elevated risk does not guarantee you will develop cancer. Similarly, a moderate or lower risk does not mean your risk is zero.
• Does this test assess the risk for my family members? No, the test evaluates your personal risk. Polygenic risk scores are not directly inherited in a way that can predict risks for relatives.
• What else should I consider alongside my test results? Your test results should be interpreted alongside other clinical data. Lifestyle, diet, and other health factors also play a role in cancer risk.